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Revisiting a controversy: The effect of EGF on EGFR dimer stability

EGFR is a receptor tyrosine kinase that plays a critical role in cell proliferation, differentiation, survival and migration. Its activating ligand, EGF, has long been believed to stabilize the EGFR dimer. Two research studies aimed at quantitative measurements of EGFR dimerization, however, have le...

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Bibliographic Details
Published in:Biochim Biophys Acta Biomembr
Main Authors: Singh, Deo R., King, Christopher, Salotto, Matt, Hristova, Kalina
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365603/
https://ncbi.nlm.nih.gov/pubmed/31295474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2019.07.003
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