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Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly
In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying mechanism remains unclear. Here, we used single-mo...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7363831/ https://ncbi.nlm.nih.gov/pubmed/32669573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68476-3 |
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