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Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly

Priming of synaptic vesicles involves Munc13‐catalyzed transition of the Munc18‐1/syntaxin‐1 complex to the SNARE complex in the presence of SNAP‐25 and synaptobrevin‐2; Munc13 drives opening of syntaxin‐1 via the MUN domain while Munc18‐1 primes SNARE assembly via domain 3a. However, the underlying...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Wang, Xianping, Gong, Jihong, Zhu, Le, Wang, Shen, Yang, Xiaoyu, Xu, Yuanyuan, Yang, Xiaofei, Ma, Cong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429736/
https://ncbi.nlm.nih.gov/pubmed/32643828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103631
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