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Munc13 activates the Munc18‐1/syntaxin‐1 complex and enables Munc18‐1 to prime SNARE assembly
Priming of synaptic vesicles involves Munc13‐catalyzed transition of the Munc18‐1/syntaxin‐1 complex to the SNARE complex in the presence of SNAP‐25 and synaptobrevin‐2; Munc13 drives opening of syntaxin‐1 via the MUN domain while Munc18‐1 primes SNARE assembly via domain 3a. However, the underlying...
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| 發表在: | EMBO J |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7429736/ https://ncbi.nlm.nih.gov/pubmed/32643828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103631 |
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