Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis

The soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) protein syntaxin‐1 adopts a closed conformation when bound to Munc18‐1, preventing binding to synaptobrevin‐2 and SNAP‐25 to form the ternary SNARE complex. Although it is known that the MUN domain of Munc13‐1 catalyze...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Wang, Shen, Choi, Ucheor B, Gong, Jihong, Yang, Xiaoyu, Li, Yun, Wang, Austin L, Yang, Xiaofei, Brunger, Axel T, Ma, Cong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350566/
https://ncbi.nlm.nih.gov/pubmed/28137749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695775
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