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Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis
The soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) protein syntaxin‐1 adopts a closed conformation when bound to Munc18‐1, preventing binding to synaptobrevin‐2 and SNAP‐25 to form the ternary SNARE complex. Although it is known that the MUN domain of Munc13‐1 catalyze...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5350566/ https://ncbi.nlm.nih.gov/pubmed/28137749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695775 |
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