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Munc13 Mediates the Transition from the Closed Syntaxin–Munc18 complex to the SNARE complex
During the priming step that leaves synaptic vesicles ready for neurotransmitter release, the SNARE syntaxin-1 transitions from a closed conformation that binds Munc18-1 tightly to an open conformation within the highly stable SNARE complex. Control of this conformational transition is key for brain...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3087822/ https://ncbi.nlm.nih.gov/pubmed/21499244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2047 |
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