Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zippering of three synaptic SNAREs (syntaxin, VAMP2, and SNAP-2...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jiao, Junyi, He, Mengze, Port, Sarah A, Baker, Richard W, Xu, Yonggang, Qu, Hong, Xiong, Yujian, Wang, Yukun, Jin, Huaizhou, Eisemann, Travis J, Hughson, Frederick M, Zhang, Yongli
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320071/
https://ncbi.nlm.nih.gov/pubmed/30540253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41771
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