Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly

In neuronal exocytosis, SNARE assembly into a stable four-helix bundle drives membrane fusion. Previous studies have revealed that the SM protein Munc18-1 plays a critical role for precise SNARE assembly with the help of Munc13-1, but the underlying mechanism remains unclear. Here, we used single-mo...

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Udgivet i:Sci Rep
Main Authors: Lee, Sanghwa, Shin, Jonghyeok, Jung, Younghun, Son, Heyjin, Shin, Jaeil, Jeong, Cherlhyun, Kweon, Dae-Hyuk, Shin, Yeon-Kyun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363831/
https://ncbi.nlm.nih.gov/pubmed/32669573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68476-3
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