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A chemical controller of SNARE-driven membrane fusion that primes vesicles for Ca(2+)-triggered millisecond exocytosis
Membrane fusion is mediated by the SNARE complex which is formed through a zippering process. Here, we developed a chemical controller for the progress of membrane fusion. A hemifusion state was arrested by a polyphenol myricetin which binds to the SNARE complex. The arrest of membrane fusion was re...
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| Pubblicato in: | J Am Chem Soc |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4852477/ https://ncbi.nlm.nih.gov/pubmed/26987363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b13449 |
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