A chemical controller of SNARE-driven membrane fusion that primes vesicles for Ca(2+)-triggered millisecond exocytosis

Membrane fusion is mediated by the SNARE complex which is formed through a zippering process. Here, we developed a chemical controller for the progress of membrane fusion. A hemifusion state was arrested by a polyphenol myricetin which binds to the SNARE complex. The arrest of membrane fusion was re...

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Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Heo, Paul, Yang, Yoosoo, Han, Kyu-Young, Kong, Byoungjae, Shin, Jong-Hyeok, Jung, Younghoon, Jeong, Cherlhyun, Shin, Jaeil, Shin, Yeon-Kyun, Ha, Taekjip, Kweon, Dae-Hyuk
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852477/
https://ncbi.nlm.nih.gov/pubmed/26987363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b13449
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