The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24

Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials targeting IL-17A in uveitis were not successful. Here, we report that Th17 cells were regulated by their own signature cytokine, I...

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Pubblicato in:Immunity
Autori principali: Chong, Wai Po, Mattapallil, Mary J., Raychaudhuri, Kumarkrishna, Bing, So Jin, Wu, Sihan, Zhong, Yajie, Wang, WeiWei, Chen, Zilin, Silver, Phyllis B., Jittayasothorn, Yingyos, Chan, Chi-Chao, Chen, Jun, Horai, Reiko, Caspi, Rachel R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362799/
https://ncbi.nlm.nih.gov/pubmed/32673565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.06.022
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