Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation

IFN-γ and IL-17A can each elicit ocular autoimmunity independently of the other. Since absence of IFN-γ or IL-17A individually failed to abolish pathology of experimental autoimmune uveitis (EAU), we examined EAU development in the absence of both these cytokines. Ifng(−/−)Il17a(−/−) mice were fully...

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Publicado en:J Autoimmun
Main Authors: Bing, So Jin, Silver, Phyllis B., Jittayasothorn, Yingyos, Mattapallil, Mary J., Chan, Chi-Chao, Horai, Reiko, Caspi, Rachel R.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572578/
https://ncbi.nlm.nih.gov/pubmed/32593472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2020.102507
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