The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24

Dysregulated Th17 cell responses underlie multiple inflammatory and autoimmune diseases, including autoimmune uveitis and its animal model, EAU. However, clinical trials targeting IL-17A in uveitis were not successful. Here, we report that Th17 cells were regulated by their own signature cytokine, I...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Chong, Wai Po, Mattapallil, Mary J., Raychaudhuri, Kumarkrishna, Bing, So Jin, Wu, Sihan, Zhong, Yajie, Wang, WeiWei, Chen, Zilin, Silver, Phyllis B., Jittayasothorn, Yingyos, Chan, Chi-Chao, Chen, Jun, Horai, Reiko, Caspi, Rachel R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362799/
https://ncbi.nlm.nih.gov/pubmed/32673565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.06.022
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados