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NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis
IFN-γ is a pathogenic cytokine involved in inflammation. Paradoxically, its deficiency exacerbates experimental autoimmune encephalomyelitis, uveitis, and arthritis. Here, we demonstrate using IFN-γ(−/−) mice repleted with IFN-γ(+/+) NK cells that innate production of IFN-γ from NK cells is necessar...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577839/ https://ncbi.nlm.nih.gov/pubmed/26347474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141678 |
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