NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ–IL-27 axis

IFN-γ is a pathogenic cytokine involved in inflammation. Paradoxically, its deficiency exacerbates experimental autoimmune encephalomyelitis, uveitis, and arthritis. Here, we demonstrate using IFN-γ(−/−) mice repleted with IFN-γ(+/+) NK cells that innate production of IFN-γ from NK cells is necessar...

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Udgivet i:J Exp Med
Main Authors: Chong, Wai Po, van Panhuys, Nicholas, Chen, Jun, Silver, Phyllis B., Jittayasothorn, Yingyos, Mattapallil, Mary J., Germain, Ronald N., Caspi, Rachel R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577839/
https://ncbi.nlm.nih.gov/pubmed/26347474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141678
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