Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

[Image: see text] Insulin-regulated aminopeptidase (IRAP) is a transmembrane zinc metallopeptidase with many important biological functions and an emerging pharmacological target. Although previous structural studies have given insight on how IRAP recognizes linear peptides, how it recognizes its ph...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Mpakali, Anastasia, Saridakis, Emmanuel, Giastas, Petros, Maben, Zachary, Stern, Lawrence J., Larhed, Mats, Hallberg, Mathias, Stratikos, Efstratios
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357224/
https://ncbi.nlm.nih.gov/pubmed/32676150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00172
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