Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP)

Macrocyclic analogues of the linear hexapeptide, angiotensin IV (AngIV) have proved to be potent inhibitors of insulin-regulated aminopeptidase (IRAP, oxytocinase, EC 3.4.11.3). Along with higher affinity, macrocycles may also offer better metabolic stability, membrane permeability and selectivity,...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Barlow, Nicholas, Vanga, Sudarsana Reddy, Sävmarker, Jonas, Sandström, Anja, Burns, Peta, Hallberg, Anders, Åqvist, Johan, Gutiérrez-de-Terán, Hugo, Hallberg, Mathias, Larhed, Mats, Chai, Siew Yeen, Thompson, Philip E.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2020
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7412577/
https://ncbi.nlm.nih.gov/pubmed/33479630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00485h
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