Inhibition of Insulin-Regulated Aminopeptidase (IRAP) by Arylsulfonamides

The inhibition of insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) by angiotenesin IV is known to improve memory and learning in rats. Screening 10 500 low-molecular-weight compounds in an enzyme inhibition assay with IRAP from Chinese Hamster Ovary (CHO) cells provided an arylsulfonamide (N-(3-...

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Vydáno v:ChemistryOpen
Hlavní autoři: Borhade, Sanjay R, Rosenström, Ulrika, Sävmarker, Jonas, Lundbäck, Thomas, Jenmalm-Jensen, Annika, Sigmundsson, Kristmundur, Axelsson, Hanna, Svensson, Fredrik, Konda, Vivek, Sköld, Christian, Larhed, Mats, Hallberg, Mathias
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280825/
https://ncbi.nlm.nih.gov/pubmed/25558444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201402027
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