Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

[Image: see text] The insulin-regulated aminopeptidase (IRAP) is a membrane-bound zinc metallopeptidase with many important regulatory functions. It has been demonstrated that inhibition of IRAP by angiotensin IV (Ang IV) and other peptides, as well as more druglike inhibitors, improves cognition in...

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Publicado en:ACS Omega
Autores principales: Vanga, Sudarsana Reddy, Sävmarker, Jonas, Ng, Leelee, Larhed, Mats, Hallberg, Mathias, Åqvist, Johan, Hallberg, Anders, Chai, Siew Yeen, Gutiérrez-de-Terán, Hugo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045421/
https://ncbi.nlm.nih.gov/pubmed/30023895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00595
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