Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

[Image: see text] The insulin-regulated aminopeptidase (IRAP) is a membrane-bound zinc metallopeptidase with many important regulatory functions. It has been demonstrated that inhibition of IRAP by angiotensin IV (Ang IV) and other peptides, as well as more druglike inhibitors, improves cognition in...

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Опубликовано в: :ACS Omega
Главные авторы: Vanga, Sudarsana Reddy, Sävmarker, Jonas, Ng, Leelee, Larhed, Mats, Hallberg, Mathias, Åqvist, Johan, Hallberg, Anders, Chai, Siew Yeen, Gutiérrez-de-Terán, Hugo
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2018
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045421/
https://ncbi.nlm.nih.gov/pubmed/30023895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00595
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