Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

[Image: see text] The insulin-regulated aminopeptidase (IRAP) is a membrane-bound zinc metallopeptidase with many important regulatory functions. It has been demonstrated that inhibition of IRAP by angiotensin IV (Ang IV) and other peptides, as well as more druglike inhibitors, improves cognition in...

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Vydáno v:ACS Omega
Hlavní autoři: Vanga, Sudarsana Reddy, Sävmarker, Jonas, Ng, Leelee, Larhed, Mats, Hallberg, Mathias, Åqvist, Johan, Hallberg, Anders, Chai, Siew Yeen, Gutiérrez-de-Terán, Hugo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2018
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6045421/
https://ncbi.nlm.nih.gov/pubmed/30023895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00595
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