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Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor

[Image: see text] Insulin-regulated aminopeptidase (IRAP) is a transmembrane zinc metallopeptidase with many important biological functions and an emerging pharmacological target. Although previous structural studies have given insight on how IRAP recognizes linear peptides, how it recognizes its ph...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Med Chem Lett
Prif Awduron: Mpakali, Anastasia, Saridakis, Emmanuel, Giastas, Petros, Maben, Zachary, Stern, Lawrence J., Larhed, Mats, Hallberg, Mathias, Stratikos, Efstratios
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2020
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7357224/
https://ncbi.nlm.nih.gov/pubmed/32676150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00172
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