ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer

Mutations in ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, are the most common alterations of the SWI/SNF complex in estrogen-receptor-positive (ER(+)) breast cancer. We identify that ARID1A inactivating mutations are present at a high frequency in advanced endocrine-resistant ER(+)...

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Publicado no:Nat Genet
Main Authors: Xu, Guotai, Chhangawala, Sagar, Cocco, Emiliano, Razavi, Pedram, Cai, Yanyan, Otto, Jordan E, Ferrando, Lorenzo, Selenica, Pier, Ladewig, Erik, Chan, Carmen, Da Cruz Paula, Arnaud, Witkin, Matthew, Cheng, Yuanming, Park, Jane, Serna-Tamayo, Cristian, Zhao, HuiYong, Wu, Fan, Sallaku, Mirna, Qu, Xuan, Zhao, Alison, Collings, Clayton K, D’Avino, Andrew R., Jhaveri, Komal, Koche, Richard, Levine, Ross L., Reis-Filho, Jorge S., Kadoch, Cigall, Scaltriti, Maurizio, Leslie, Christina S., Baselga, José, Toska, Eneda
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341683/
https://ncbi.nlm.nih.gov/pubmed/31932695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0554-0
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