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Delineation of the molecular determinants of the unique allosteric binding site of the orphan nuclear receptor RORγt
Nuclear receptors (NRs) are high-interest targets in drug discovery because of their involvement in numerous biological processes and diseases. Classically, NRs are targeted via their hydrophobic, orthosteric pocket. Although successful, this approach comes with challenges, including off-target effe...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7335795/ https://ncbi.nlm.nih.gov/pubmed/32439807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013581 |
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