Identification of an allosteric binding site for RORγt inhibition

RORγt is critical for the differentiation and proliferation of Th17 cells associated with several chronic autoimmune diseases. We report the discovery of a novel allosteric binding site on the nuclear receptor RORγt. Co-crystallization of the ligand binding domain (LBD) of RORγt with a series of sma...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Scheepstra, Marcel, Leysen, Seppe, van Almen, Geert C., Miller, J. Richard, Piesvaux, Jennifer, Kutilek, Victoria, van Eenennaam, Hans, Zhang, Hongjun, Barr, Kenneth, Nagpal, Sunil, Soisson, Stephen M., Kornienko, Maria, Wiley, Kristen, Elsen, Nathaniel, Sharma, Sujata, Correll, Craig C., Trotter, B. Wesley, van der Stelt, Mario, Oubrie, Arthur, Ottmann, Christian, Parthasarathy, Gopal, Brunsveld, Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4686831/
https://ncbi.nlm.nih.gov/pubmed/26640126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9833
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