Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolog (SIAH-1), and in the nucleus it directly interacts...

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Publicado en:Hum Mol Genet
Main Authors: Shani, Vered, Safory, Hazem, Szargel, Raymonde, Wang, Ninghan, Cohen, Tsipora, Elghani, Fatimah Abd, Hamza, Haya, Savyon, Mor, Radzishevsky, Inna, Shaulov, Lihi, Rott, Ruth, Lim, Kah-Leong, Ross, Christopher A, Bandopadhyay, Rina, Zhang, Hui, Engelender, Simone
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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General Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335485/
https://ncbi.nlm.nih.gov/pubmed/31626293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz245
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