SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation

α-Synuclein accumulation is a pathological hallmark of Parkinson’s disease (PD). Ubiquitinated α-synuclein is targeted to proteasomal or lysosomal degradation. Here, we identify SUMOylation as a major mechanism that counteracts ubiquitination by different E3 ubiquitin ligases and regulates α-synucle...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rott, Ruth, Szargel, Raymonde, Shani, Vered, Hamza, Haya, Savyon, Mor, Abd Elghani, Fatimah, Bandopadhyay, Rina, Engelender, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740625/
https://ncbi.nlm.nih.gov/pubmed/29180403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704351114
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