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α-Synuclein fate is determined by USP9X-regulated monoubiquitination
α-Synuclein is central to the pathogenesis of Parkinson disease (PD). Mutations as well as accumulation of α-synuclein promote the death of dopaminergic neurons and the formation of Lewy bodies. α-Synuclein is monoubiquitinated by SIAH, but the regulation and roles of monoubiquitination in α-synucle...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3219120/ https://ncbi.nlm.nih.gov/pubmed/22065755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105725108 |
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