Synphilin-1A Inhibits Seven in Absentia Homolog (SIAH) and Modulates α-Synuclein Monoubiquitylation and Inclusion Formation

Parkinson disease (PD) is characterized by the presence of ubiquitylated inclusions and the death of dopaminergic neurons. Seven in absentia homolog (SIAH) is a ubiquitin-ligase that ubiquitylates α-synuclein and synphilin-1 and is present in Lewy bodies of PD patients. Understanding the mechanisms...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Szargel, Raymonde, Rott, Ruth, Eyal, Allon, Haskin, Joseph, Shani, Vered, Balan, Livia, Wolosker, Herman, Engelender, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670174/
https://ncbi.nlm.nih.gov/pubmed/19224863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805990200
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados