Synphilin-1A Inhibits Seven in Absentia Homolog (SIAH) and Modulates α-Synuclein Monoubiquitylation and Inclusion Formation

Parkinson disease (PD) is characterized by the presence of ubiquitylated inclusions and the death of dopaminergic neurons. Seven in absentia homolog (SIAH) is a ubiquitin-ligase that ubiquitylates α-synuclein and synphilin-1 and is present in Lewy bodies of PD patients. Understanding the mechanisms...

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Autors principals: Szargel, Raymonde, Rott, Ruth, Eyal, Allon, Haskin, Joseph, Shani, Vered, Balan, Livia, Wolosker, Herman, Engelender, Simone
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670174/
https://ncbi.nlm.nih.gov/pubmed/19224863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805990200
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