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AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease
Parkin E3 ubiquitin-ligase activity and its role in mitochondria homeostasis are thought to play a role in Parkinson's disease (PD). We now report that AF-6 is a novel parkin interacting protein that modulates parkin ubiquitin-ligase activity and mitochondrial roles. Parkin interacts with the A...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3803144/ https://ncbi.nlm.nih.gov/pubmed/23393160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt058 |
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