Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolog (SIAH-1), and in the nucleus it directly interacts...

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Foilsithe in:Hum Mol Genet
Main Authors: Shani, Vered, Safory, Hazem, Szargel, Raymonde, Wang, Ninghan, Cohen, Tsipora, Elghani, Fatimah Abd, Hamza, Haya, Savyon, Mor, Radzishevsky, Inna, Shaulov, Lihi, Rott, Ruth, Lim, Kah-Leong, Ross, Christopher A, Bandopadhyay, Rina, Zhang, Hui, Engelender, Simone
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2019
Ábhair:
General Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335485/
https://ncbi.nlm.nih.gov/pubmed/31626293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz245
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