Physiological and pathological roles of LRRK2 in the nuclear envelope integrity

Mutations in LRRK2 cause autosomal dominant and sporadic Parkinson’s disease, but the mechanisms involved in LRRK2 toxicity in PD are yet to be fully understood. We found that LRRK2 translocates to the nucleus by binding to seven in absentia homolog (SIAH-1), and in the nucleus it directly interacts...

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Dettagli Bibliografici
Pubblicato in:Hum Mol Genet
Autori principali: Shani, Vered, Safory, Hazem, Szargel, Raymonde, Wang, Ninghan, Cohen, Tsipora, Elghani, Fatimah Abd, Hamza, Haya, Savyon, Mor, Radzishevsky, Inna, Shaulov, Lihi, Rott, Ruth, Lim, Kah-Leong, Ross, Christopher A, Bandopadhyay, Rina, Zhang, Hui, Engelender, Simone
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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General Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335485/
https://ncbi.nlm.nih.gov/pubmed/31626293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz245
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