Therapeutic targeting of the secreted lysophospholipase D autotaxin suppresses tuberous sclerosis complex-associated tumorigenesis

Tuberous Sclerosis Complex (TSC) is an autosomal dominant disease characterized by multi-organ hamartomas, including renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM). TSC2 deficiency leads to hyperactivation of mammalian Target of Rapamycin Complex 1 (mTORC1), a master regulator of...

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Pubblicato in:Cancer Res
Autori principali: Feng, You, Mischler, William J., Gurung, Ashish C., Kavanagh, Taylor R., Androsov, Grigoriy, Sadow, Peter M., Herbert, Zachary T., Priolo, Carmen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335343/
https://ncbi.nlm.nih.gov/pubmed/32393662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2884
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