Therapeutic targeting of the secreted lysophospholipase D autotaxin suppresses tuberous sclerosis complex-associated tumorigenesis

Tuberous Sclerosis Complex (TSC) is an autosomal dominant disease characterized by multi-organ hamartomas, including renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM). TSC2 deficiency leads to hyperactivation of mammalian Target of Rapamycin Complex 1 (mTORC1), a master regulator of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Feng, You, Mischler, William J., Gurung, Ashish C., Kavanagh, Taylor R., Androsov, Grigoriy, Sadow, Peter M., Herbert, Zachary T., Priolo, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335343/
https://ncbi.nlm.nih.gov/pubmed/32393662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-2884
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados