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A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of MHAA4549A, a Monoclonal Antibody, plus Oseltamivir in Patients Hospitalized with Severe Influenza A Virus Infection

For patients hospitalized with severe influenza A virus infection, morbidity and mortality remain high. MHAA4549A, a human monoclonal antibody targeting the influenza A virus hemagglutinin stalk, has demonstrated pharmacological activity in animal studies and in a human influenza A challenge study....

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發表在:Antimicrob Agents Chemother
Main Authors: Lim, Jeremy J., Nilsson, Anna C., Silverman, Michael, Assy, Nimer, Kulkarni, Priya, McBride, Jacqueline M., Deng, Rong, Li, Chloe, Yang, Xiaoying, Nguyen, Allen, Horn, Priscilla, Maia, Mauricio, Castro, Aide, Peck, Melicent C., Galanter, Joshua, Chu, Tom, Newton, Elizabeth M., Tavel, Jorge A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318030/
https://ncbi.nlm.nih.gov/pubmed/32393496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00352-20
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