Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension

Oxidative damage is implicated in atrial fibrillation (AF), but antioxidants are ineffective therapeutically. The authors tested the hypothesis that highly reactive lipid dicarbonyl metabolites, or isolevuglandins (IsoLGs), are principal drivers of AF during hypertension. In a hypertensive murine mo...

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Bibliografiske detaljer
Udgivet i:JACC Basic Transl Sci
Main Authors: Prinsen, Joseph K., Kannankeril, Prince J., Sidorova, Tatiana N., Yermalitskaya, Liudmila V., Boutaud, Olivier, Zagol-Ikapitte, Irene, Barnett, Joey V., Murphy, Matthew B., Subati, Tuerdi, Stark, Joshua M., Christopher, Isis L., Jafarian-Kerman, Scott R., Saleh, Mohamed A., Norlander, Allison E., Loperena, Roxana, Atkinson, James B., Fogo, Agnes B., Luther, James M., Amarnath, Venkataraman, Davies, Sean S., Kirabo, Annet, Madhur, Meena S., Harrison, David G., Murray, Katherine T.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
PRECLINICAL RESEARCH
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315188/
https://ncbi.nlm.nih.gov/pubmed/32613146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.04.004
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