Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function

The metabolism-controlled differentiation of αβ T cells has been well documented; however, the role of a metabolism program in γδ T cell differentiation and function has not been clarified. Here, using CD2-cre; mTORC1 Raptor-f/f, and mTORC2 Rictor-f/f mice (KO mice), we found that mTORC1, but not mT...

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Vydáno v:Cell Death Differ
Hlavní autoři: Yang, Quanli, Liu, Xia, Liu, Qihui, Guan, Zerong, Luo, Jing, Cao, Guangchao, Cai, Ruitian, Li, Zhenhua, Xu, Yan, Wu, Zengfeng, Xu, Miaomiao, Zhang, Song, Zhang, Fan, Yang, Hengwen, Lin, Xuejia, Yang, Meixiang, Wu, Yangzhe, Gao, Yunfei, Flavell, Richard, Hao, Jianlei, Yin, Zhinan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308385/
https://ncbi.nlm.nih.gov/pubmed/32001780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0500-9
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