GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity

Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR downregulation in WAT of patients with diabetes are not well understood. By using multiple mouse models of obesit...

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Publicat a:JCI Insight
Autors principals: Hauffe, Robert, Stein, Vanessa, Chudoba, Chantal, Flore, Tanina, Rath, Michaela, Ritter, Katrin, Schell, Mareike, Wardelmann, Kristina, Deubel, Stefanie, Kopp, Johannes Florian, Schwarz, Maria, Kappert, Kai, Blüher, Matthias, Schwerdtle, Tanja, Kipp, Anna P., Kleinridders, André
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308064/
https://ncbi.nlm.nih.gov/pubmed/32369454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136283
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