GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity

Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR downregulation in WAT of patients with diabetes are not well understood. By using multiple mouse models of obesit...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hauffe, Robert, Stein, Vanessa, Chudoba, Chantal, Flore, Tanina, Rath, Michaela, Ritter, Katrin, Schell, Mareike, Wardelmann, Kristina, Deubel, Stefanie, Kopp, Johannes Florian, Schwarz, Maria, Kappert, Kai, Blüher, Matthias, Schwerdtle, Tanja, Kipp, Anna P., Kleinridders, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308064/
https://ncbi.nlm.nih.gov/pubmed/32369454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136283
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