GPx3 dysregulation impacts adipose tissue insulin receptor expression and sensitivity

Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR downregulation in WAT of patients with diabetes are not well understood. By using multiple mouse models of obesit...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Hauffe, Robert, Stein, Vanessa, Chudoba, Chantal, Flore, Tanina, Rath, Michaela, Ritter, Katrin, Schell, Mareike, Wardelmann, Kristina, Deubel, Stefanie, Kopp, Johannes Florian, Schwarz, Maria, Kappert, Kai, Blüher, Matthias, Schwerdtle, Tanja, Kipp, Anna P., Kleinridders, André
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308064/
https://ncbi.nlm.nih.gov/pubmed/32369454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136283
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