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Acute manganese treatment restores defective autophagic cargo loading in Huntington’s disease cell lines
The molecular etiology linking the pathogenic mutations in the Huntingtin (Htt) gene with Huntington’s disease (HD) is unknown. Prior work suggests a role for Htt in neuronal autophagic function and mutant HTT protein disrupts autophagic cargo loading. Reductions in the bioavailability of the essent...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7305814/ https://ncbi.nlm.nih.gov/pubmed/31600787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz209 |
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