Acute manganese treatment restores defective autophagic cargo loading in Huntington’s disease cell lines

The molecular etiology linking the pathogenic mutations in the Huntingtin (Htt) gene with Huntington’s disease (HD) is unknown. Prior work suggests a role for Htt in neuronal autophagic function and mutant HTT protein disrupts autophagic cargo loading. Reductions in the bioavailability of the essent...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Bryan, Miles R, O’Brien, Michael T, Nordham, Kristen D, Rose, Daniel I R, Foshage, Audra M, Joshi, Piyush, Nitin, Rachana, Uhouse, Michael A, Di Pardo, Alba, Zhang, Ziyan, Maglione, Vittorio, Aschner, Michael, Bowman, Aaron B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305814/
https://ncbi.nlm.nih.gov/pubmed/31600787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz209
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