Acute manganese treatment restores defective autophagic cargo loading in Huntington’s disease cell lines

The molecular etiology linking the pathogenic mutations in the Huntingtin (Htt) gene with Huntington’s disease (HD) is unknown. Prior work suggests a role for Htt in neuronal autophagic function and mutant HTT protein disrupts autophagic cargo loading. Reductions in the bioavailability of the essent...

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Udgivet i:Hum Mol Genet
Main Authors: Bryan, Miles R, O’Brien, Michael T, Nordham, Kristen D, Rose, Daniel I R, Foshage, Audra M, Joshi, Piyush, Nitin, Rachana, Uhouse, Michael A, Di Pardo, Alba, Zhang, Ziyan, Maglione, Vittorio, Aschner, Michael, Bowman, Aaron B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7305814/
https://ncbi.nlm.nih.gov/pubmed/31600787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz209
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