Manganese acts upon Insulin/IGF receptors to phosphorylate AKT and increase glucose uptake in Huntington’s Disease cells

Perturbations in insulin/IGF signaling and manganese (Mn(2+)) uptake and signaling have been separately reported in Huntington’s disease (HD) models. Insulin/IGF supplementation ameliorates HD phenotypes via upregulation of AKT, a known Mn(2+)-responsive kinase. Limited evidence both in vivo and in...

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Pubblicato in:Mol Neurobiol
Autori principali: Bryan, Miles R., Nordham, Kristen D., Rose, Daniel I.R., O’Brien, Michael T., Joshi, Piyush, Foshage, Audra M., Gonçalves, Filipe M., Nitin, Rachana, Uhouse, Michael A., Aschner, Michael, Bowman, Aaron B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062569/
https://ncbi.nlm.nih.gov/pubmed/31797328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-01824-1
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