Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line

In a recent study, we found that blocking the protein kinase ataxia telangiectasia mutated (ATM) with the small molecule inhibitor (SMI) KU-55933 can completely abrogate Mn-induced phosphorylation of p53 at serine 15 (p-p53) in human induced pluripotent stem cell (hiPSC)-differentiated striatal neur...

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Detalhes bibliográficos
Publicado no:Neurotoxicology
Main Authors: Bryan, Miles R., Uhouse, Michael A., Nordham, Kristen D., Joshi, Piyush, Rose, Daniel I.R., O’Brien, Michael T., Aschner, Michael, Bowman, Aaron B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796869/
https://ncbi.nlm.nih.gov/pubmed/28780388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2017.07.026
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