Altered Manganese Homeostasis and Manganese Toxicity in a Huntington's Disease Striatal Cell Model Are Not Explained by Defects in the Iron Transport System

Expansion of a polyglutamine tract in Huntingtin (Htt) leads to the degeneration of medium spiny neurons in Huntington's disease (HD). Furthermore, the HTT gene has been functionally linked to iron (Fe) metabolism, and HD patients show alterations in brain and peripheral Fe homeostasis. Recentl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Williams, B. Blairanne, Kwakye, Gunnar F., Wegrzynowicz, Michal, Li, Daphne, Aschner, Michael, Erikson, Keith M., Bowman, Aaron B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Neurotoxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923282/
https://ncbi.nlm.nih.gov/pubmed/20547568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq174
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados