Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington’s disease mouse model

Huntington’s disease (HD) is caused by a mutation in the huntingtin gene (HTT), resulting in profound striatal neurodegeneration through an unknown mechanism. Perturbations in the urea cycle have been reported in HD models and in HD patient blood and brain. In neurons, arginase is a central urea cyc...

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Publicado no:Biochim Biophys Acta
Main Authors: Bichell, Terry Jo V., Wegrzynowicz, Michal, Tipps, K. Grace, Bradley, Emma M., Uhouse, Michael A., Bryan, Miles, Horning, Kyle, Fisher, Nicole, Dudek, Karrie, Halbesma, Timothy, Umashanker, Preethi, Stubbs, Andrew D., Holt, Hunter K., Kwakye, Gunnar F., Tidball, Andrew M., Colbran, Roger J., Aschner, Michael, Neely, M. Diana, Di Pardo, Alba, Maglione, Vittorio, Osmand, Alexander, Bowman, Aaron B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515276/
https://ncbi.nlm.nih.gov/pubmed/28213125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2017.02.013
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