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A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

The essential micronutrient manganese is enriched in brain, especially in the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, as previous data suggested that alterations in striatal manganese handling occur in Huntington's...

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Bibliografski detalji
Izdano u:Hum Mol Genet
Glavni autori: Tidball, Andrew M., Bryan, Miles R., Uhouse, Michael A., Kumar, Kevin K., Aboud, Asad A., Feist, Jack E., Ess, Kevin C., Neely, M. Diana, Aschner, Michael, Bowman, Aaron B.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355025/
https://ncbi.nlm.nih.gov/pubmed/25489053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu609
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