Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells

Alterations in DNA damage response and repair have been observed in Huntington’s disease (HD). We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects. A significant fraction of the HD iPSC lines had genomic abnormalities as ass...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Tidball, Andrew M., Neely, M. Diana, Chamberlin, Reed, Aboud, Asad A., Kumar, Kevin K., Han, Bingying, Bryan, Miles R., Aschner, Michael, Ess, Kevin C., Bowman, Aaron B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794230/
https://ncbi.nlm.nih.gov/pubmed/26982737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150372
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