Genomic Instability Associated with p53 Knockdown in the Generation of Huntington’s Disease Human Induced Pluripotent Stem Cells

Alterations in DNA damage response and repair have been observed in Huntington’s disease (HD). We generated induced pluripotent stem cells (iPSC) from primary dermal fibroblasts of 5 patients with HD and 5 control subjects. A significant fraction of the HD iPSC lines had genomic abnormalities as ass...

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Bibliographic Details
Published in:PLoS One
Main Authors: Tidball, Andrew M., Neely, M. Diana, Chamberlin, Reed, Aboud, Asad A., Kumar, Kevin K., Han, Bingying, Bryan, Miles R., Aschner, Michael, Ess, Kevin C., Bowman, Aaron B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794230/
https://ncbi.nlm.nih.gov/pubmed/26982737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150372
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