Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese

Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures. Conducting a screen of small molecules known to alter cellular Mn levels, we report here that one of these chemicals induces rapid Mn efflux. We de...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Horning, Kyle J., Joshi, Piyush, Nitin, Rachana, Balachandran, Rekha C., Yanko, Frank M., Kim, Kwangho, Christov, Plamen, Aschner, Michael, Sulikowski, Gary A., Weaver, C. David, Bowman, Aaron B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Methods and Resources
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7086026/
https://ncbi.nlm.nih.gov/pubmed/32047113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009781
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