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GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation
Cells perceive and respond to the extracellular matrix via integrin receptors; their dysregulation has been implicated in inflammation and cancer metastasis. Here we show that a guanine nucleotide-exchange modulator of trimeric-GTPase Gαi, GIV (a.k.a Girdin), directly binds the integrin adaptor Kind...
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| Publicat a: | iScience |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7300163/ https://ncbi.nlm.nih.gov/pubmed/32535026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101209 |
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