GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation

Cells perceive and respond to the extracellular matrix via integrin receptors; their dysregulation has been implicated in inflammation and cancer metastasis. Here we show that a guanine nucleotide-exchange modulator of trimeric-GTPase Gαi, GIV (a.k.a Girdin), directly binds the integrin adaptor Kind...

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Udgivet i:iScience
Main Authors: Rohena, Cristina, Kalogriopoulos, Nicholas, Rajapakse, Navin, Roy, Suchismita, Lopez-Sanchez, Inmaculada, Ablack, Jailal, Sahoo, Debashis, Ghosh, Pradipta
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300163/
https://ncbi.nlm.nih.gov/pubmed/32535026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101209
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