GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation

Summary: Cells perceive and respond to the extracellular matrix via integrin receptors; their dysregulation has been implicated in inflammation and cancer metastasis. Here we show that a guanine nucleotide-exchange modulator of trimeric-GTPase Gαi, GIV (a.k.a Girdin), directly binds the integrin ada...

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Detalhes bibliográficos
Main Authors: Cristina Rohena, Nicholas Kalogriopoulos, Navin Rajapakse, Suchismita Roy, Inmaculada Lopez-Sanchez, Jailal Ablack, Debashis Sahoo, Pradipta Ghosh
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-06-01
Colecção:iScience
Assuntos:
Biological Sciences
Molecular Biology
Cell Biology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589004220303941
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