Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

[Image: see text] Covalent modification of disease-associated proteins with small molecules is a powerful approach for achieving an increased and sustained pharmacological effect. To reduce the potential risk of nonselective covalent modification, molecular design of covalent inhibitors is criticall...

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Opis bibliograficzny
Wydane w:ACS Med Chem Lett
Główni autorzy: Sato, Mami, Fuchida, Hirokazu, Shindo, Naoya, Kuwata, Keiko, Tokunaga, Keisuke, Xiao-Lin, Guo, Inamori, Ryo, Hosokawa, Keitaro, Watari, Kosuke, Shibata, Tomohiro, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro, Ono, Mayumi, Ojida, Akio
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2020
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294701/
https://ncbi.nlm.nih.gov/pubmed/32550993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00574
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