Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα

Xanthine oxidase (XOD), also known as xanthine dehydrogenase, is a rate-limiting enzyme in purine nucleotide degradation, which produces uric acid. Uric acid concentrations in the blood and liver exhibit circadian oscillations in both humans and rodents; however, the underlying mechanisms remain unc...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kanemitsu, Takumi, Tsurudome, Yuya, Kusunose, Naoki, Oda, Masayuki, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766946/
https://ncbi.nlm.nih.gov/pubmed/29101234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.791285
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