Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

The expression and function of some xenobiotic transporters varies according to the time of day, causing the dosing time-dependent changes in drug disposition and toxicity. Multidrug resistance-associated protein-4 (MRP4), an ATP­binding cassette (ABC) efflux transporter encoded by the Abcc4 gene, i...

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Publicat a:Sci Rep
Autors principals: Kato, Mizuki, Tsurudome, Yuya, Kanemitsu, Takumi, Yasukochi, Sai, Kanado, Yuki, Ogino, Takashi, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7417537/
https://ncbi.nlm.nih.gov/pubmed/32778717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70321-6
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