Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity in sciatic nerve-injured mice shows pronounced diurnal alterations, which critically depend on diurnal variations in gl...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Koyanagi, Satoru, Kusunose, Naoki, Taniguchi, Marie, Akamine, Takahiro, Kanado, Yuki, Ozono, Yui, Masuda, Takahiro, Kohro, Yuta, Matsunaga, Naoya, Tsuda, Makoto, Salter, Michael W., Inoue, Kazuhide, Ohdo, Shigehiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067584/
https://ncbi.nlm.nih.gov/pubmed/27739425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13102
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